Pathology >> ALS | Alzheimer's | SCI

alzheimer's disease

Millions of people are diagnosed with AD each year. Like ALS, the exact etiology is not fully known as the disease is mult-factorial, involving several cellular processes. As such there are no cures and limited success with treatments that aim to slow the disease. We strongly believe that pathology dynamics has a lot to offer the field and the patients who suffer from devastating dementia and seizures. Alzheimer's Disease (AD) is our newest test pathology, but we have outlined several projects with the ultimate goal of illuminating AD's elusive system dynamics.

Alzheimer's Disease Quantitative Database

Like any pathology, the first step is to gather all of the data. We are working on a novel comprehensive database that gathers figure-level, quantifiable data from the 85,000+ journal articles that have been published to date on AD (any article that Alzheimer's Disease in the title or abstract). This database gathers information in articles that is currently not obtainable through traditional search engines such as PubMed, EndNote, etc. It will take a combination of automation and tedious, laborious manual entry to fully achieve. While this is admittingly a daunting task, it is an important first-step not only to pursue pathology dynamics, but also to assist the thousands of other AD researchers in finding the information they need to make decisions regarding their own experimental and clinical projects.

Tg2576 Alzheimer's Disease transgenic mouse model

There are numerous transgenic model models utilized to examine AD, and each one is used for its different characteristics, which favor the study of a specific symptom, process or treatment. Much unlike ALS where >80% of the publications use the G93A transgenic mouse model, there is not exactly one primary stand-out model for AD. Nonetheless, the Tg2576 has a slight edge in terms of its popularity for experimental AD research over other transgenic models. Since it has the largest number of publications compared to other AD mouse models, we have chose it as our initial basis for pursuing pathology dynamics. We have already developed a Tg2576 transgenic mouse model database that contains figure-level information and data for the 400+ papers that have been published. We are currently examining extractable relationships, including cellular mechanisms and outcome measures, which can be used to construct the pathology system structure (for an example of a simplified pathology system structure, see ALS pathology structure). Once this preliminary structure is complete for AD we will begin our examination and analysis of pathology dynamics.

Foley AM, Ammar ZM, Lee RH, Mitchell CS.  (2015).  Systematic review of the relationship between amyloid-β levels and measures of transgenic mouse cognitive deficit in Alzheimer's disease.  J Alzheimers Dis. 2015 Jan 1;44(3):787-95.